Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2012 1
2019 6
2020 4
2021 1
2022 1
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

13 results

Results by year

Filters applied: . Clear all
Page 1
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, Chen S, Zhu Y, Mei M, Bao S, Liu W, Tang Z, Sun Q. Ding X, et al. Autophagy. 2019 Oct;15(10):1774-1786. doi: 10.1080/15548627.2019.1596478. Epub 2019 Apr 6. Autophagy. 2019. PMID: 30957628 Free PMC article.
Abbreviations: ACTB: actin beta; ATG9: autophagy related 9A; ATG14: autophagy related 14; ATG16L1: autophagy related 16 like 1; BCAP31: B cell receptor associated protein 31; BECN1: beclin 1; Ctrl: control; CQ: chloroquine; CTSD: cathepsin D; DMSO: dimethyl sulfoxide; EBSS: Earle …
Abbreviations: ACTB: actin beta; ATG9: autophagy related 9A; ATG14: autophagy related 14; ATG16L1: autophagy related 16 like 1; BCAP31: B ce …
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y. Matsuda J, et al. Autophagy. 2020 Oct;16(10):1889-1904. doi: 10.1080/15548627.2020.1712107. Epub 2020 Jan 16. Autophagy. 2020. PMID: 31944172 Free PMC article.
Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area under the curve; Baf: bafilomycin A(1); BAT: brown adipose tissue; BODIPY: boron-dipyrromethene; BSA: bovine serum albumin; BW: body weight; …
Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area u …
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J. Zhou C, et al. Autophagy. 2021 Oct;17(10):3175-3195. doi: 10.1080/15548627.2020.1826689. Epub 2020 Oct 22. Autophagy. 2021. PMID: 32972302 Free PMC article.
Our findings suggest that components of the MIR454-FAM83A-TSPAN1 axis may be valuable prognosis markers or therapeutic targets for pancreatic cancer.Abbreviations: AMPK: adenosine 5'-monophosphate (AMP)-activated protein kinase; APC: APC regulator of WNT signaling pathway; ATG: a …
Our findings suggest that components of the MIR454-FAM83A-TSPAN1 axis may be valuable prognosis markers or therapeutic targets for pancreati …
The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells.
Koch J, Xin Q, Obr M, Schäfer A, Rolfs N, Anagho HA, Kudulyte A, Woltereck L, Kummer S, Campos J, Uckeley ZM, Bell-Sakyi L, Kräusslich HG, Schur FK, Acuna C, Lozach PY. Koch J, et al. PLoS Pathog. 2023 Aug 14;19(8):e1011562. doi: 10.1371/journal.ppat.1011562. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37578957 Free PMC article.
Investigating iPSC-derived human neurons and cell lines, we found that virus binding to the cell surface was specific, and 50% of bound virions were endocytosed within 10 min. Virions entered Rab5a+ early endosomes and, subsequently, Rab7a+ and LAMP-1+ late endosomal compa …
Investigating iPSC-derived human neurons and cell lines, we found that virus binding to the cell surface was specific, and 50% of bound viri …
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J. Tian X, et al. Autophagy. 2020 May;16(5):797-810. doi: 10.1080/15548627.2019.1637199. Epub 2019 Jul 4. Autophagy. 2020. PMID: 31251111 Free PMC article.
Thus, we reveal a new aspect of autophagosome-lysosome fusion in which different isoforms of VAMP7 compete with STX17 and their regulation by DIPK2A.Abbreviations: DIPK2A: divergent protein kinase domain 2A; EEA1: early endosome antigen 1; GOLGA2: golgin A2; LAMP1: lysosom …
Thus, we reveal a new aspect of autophagosome-lysosome fusion in which different isoforms of VAMP7 compete with STX17 and their regulation b …
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Lin Y, Wu C, Wang X, Liu S, Zhao K, Kemper T, Yu H, Li M, Zhang J, Chen M, Zhu Y, Chen X, Lu M. Lin Y, et al. Autophagy. 2020 Mar;16(3):548-561. doi: 10.1080/15548627.2019.1632104. Epub 2019 Jun 23. Autophagy. 2020. PMID: 31204557 Free PMC article.
Thus, there is a potential risk of enhanced viral replication by oral GlcN intake in chronically virally infected patients.Abbreviations: ACTB: actin beta; ATG: autophagy-related; CMIA: chemiluminescence immunoassay; ConA: concanavalin A; CQ: chloroquine; CTSD: cathepsin D; DAPI: …
Thus, there is a potential risk of enhanced viral replication by oral GlcN intake in chronically virally infected patients.Abbreviations: AC …
The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes.
Windhaber S, Xin Q, Uckeley ZM, Koch J, Obr M, Garnier C, Luengo-Guyonnot C, Duboeuf M, Schur FKM, Lozach PY. Windhaber S, et al. J Virol. 2022 Mar 9;96(5):e0214621. doi: 10.1128/jvi.02146-21. Epub 2022 Jan 12. J Virol. 2022. PMID: 35019710 Free PMC article.
The virus entered Rab5a-positive (Rab5a(+)) early endosomes and, subsequently, late endosomal vacuoles containing Rab7a but not LAMP-1. Infectious entry did not require proteolytic cleavage, and endosomal acidification was sufficient and necessary for viral fusion. ...
The virus entered Rab5a-positive (Rab5a(+)) early endosomes and, subsequently, late endosomal vacuoles containing Rab7a but not LAMP- …
Junín virus induces autophagy in human A549 cells.
Perez Vidakovics MLA, Ure AE, Arrías PN, Romanowski V, Gómez RM. Perez Vidakovics MLA, et al. PLoS One. 2019 Jun 19;14(6):e0218730. doi: 10.1371/journal.pone.0218730. eCollection 2019. PLoS One. 2019. PMID: 31216340 Free PMC article.
Furthermore, JUNV infection induced the colocalisation of p62, ATG16, RAB5, RAB7A and LAMP1 with the autophagosomal LC3 protein. That suggests that phagosomes undergo the maturation process during viral infection. ...
Furthermore, JUNV infection induced the colocalisation of p62, ATG16, RAB5, RAB7A and LAMP1 with the autophagosomal LC3 protei …
Effect of rapamycin on lysosomal accumulation in a CRISPR/Cas9-based cellular model of VPS13A deficiency.
Tornero-Écija AR, Navas MA, Muñoz-Braceras S, Vincent O, Escalante R. Tornero-Écija AR, et al. J Cell Mol Med. 2023 Jun;27(11):1557-1564. doi: 10.1111/jcmm.17768. Epub 2023 May 10. J Cell Mol Med. 2023. PMID: 37163371 Free PMC article.
Consistent with previous observations by siRNA inactivation, VPS13A inactivation by CRISPR/Cas9 resulted in accumulation of the endo-lysosomal markers RAB7A and LAMP1. Notably, we observed that rapamycin partially suppressed the difference in lysosome accumulation b …
Consistent with previous observations by siRNA inactivation, VPS13A inactivation by CRISPR/Cas9 resulted in accumulation of the endo-lysosom …
VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation.
Muñoz-Braceras S, Tornero-Écija AR, Vincent O, Escalante R. Muñoz-Braceras S, et al. Dis Model Mech. 2019 Feb 22;12(2):dmm036681. doi: 10.1242/dmm.036681. Dis Model Mech. 2019. PMID: 30709847 Free PMC article.
However, the mechanistic details of this deficiency are unknown. Here, we identified Rab7A as an interactor of one of the VPS13 family members in Dictyostelium discoideum and showed that this interaction is conserved between the human homologs VPS13A and RAB7A in He …
However, the mechanistic details of this deficiency are unknown. Here, we identified Rab7A as an interactor of one of the VPS13 famil …
13 results